2-甲基-2-丙基3-硝基-7,8-二氢-1,6-萘啶-6(5H)-羧酸酯合成路线 （共 4 条）
反应条件
ammonia in methanol T=120°C; Inverse electron demand Diels-Alder reaction; 0.333333 h; Microwave irradiation;
参考文献
Guiadeen, Deodialsingh; Kothandaraman, Shankaran; Yang, Lihu; Mills, Sander G.; MacCoss, Malcolm
Tetrahedron Letters, 2008 , vol. 49, # 44 p. 6368 - 6370
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Harling; Harrington; Thompson
Synthetic Communications, 2001 , vol. 31, # 5 p. 787 - 797
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 18 h;
参考文献
Shah, Unmesh; Lankin, Claire M.; Boyle, Craig D.; Chackalamannil, Samuel; Greenlee, William J.; Neustadt, Bernard R.; Cohen-Williams, Mary E.; Higgins, Guy A.; Ng, Kwokei; Varty, Geoffrey B.; Zhang, Hongtao; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4204 - 4209
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=170°C; 176 h; sealed tube;
参考文献
AMGEN INC.
Patent: WO2007/48070 A2, 2007 ;
Location in patent: Page/Page column 107 ;
