N-(1-乙基丙基)-6-甲基-吡嗪胺合成路线 （共 3 条）
反应条件
1: 6-chloro-[N-(1-ethyl)propyl]pyrazine-2-amine With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran T=20°C; 0.166667 h; 2: methylmagnesium bromide in tetrahydrofuran; diethyl ether T=0 - 20°C; 1 h;
参考文献
NEUROGEN CORPORATION
Patent: WO2004/18437 A1, 2004 ;
Location in patent: Page 38 ;
WO 2004/018437 A1
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran T=10 - 15°C; Kumada coupling reaction; 6 h;
参考文献
Hodgetts, Kevin J.; Ge, Ping; Yoon, Taeyoung; Lombaert, Stephane De; Brodbeck, Robbin; Gulianello, Michael; Kieltyka, Andrzej; Horvath, Raymond F.; Kehne, John H.; Krause, James E.; Maynard, George D.; Hoffman, Diane; Lee, Younglim; Fung, Laurence; Doller, Dario
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4187 - 4206
反应条件
1: triethylamine / propan-1-ol / 12 h / 98 °C 2: [1,3-bis(diphenylphosphino) propane] dichloronickel(II) / tetrahydrofuran / 6 h / 10 - 15 °C View Scheme
参考文献
Hodgetts, Kevin J.; Ge, Ping; Yoon, Taeyoung; Lombaert, Stephane De; Brodbeck, Robbin; Gulianello, Michael; Kieltyka, Andrzej; Horvath, Raymond F.; Kehne, John H.; Krause, James E.; Maynard, George D.; Hoffman, Diane; Lee, Younglim; Fung, Laurence; Doller, Dario
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4187 - 4206
