4-甲氧基-2-甲基苯甲酸甲酯合成路线 （共 27 条）
反应条件
thionyl chloride T=20°C; Reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/5998 A1, 2009 ;
Location in patent: Page/Page column 214 ;
反应条件
caesium carbonate in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
WO2011/156518 A2, ;
Page/Page column 115 ;
WO 2011/156518 A2
反应条件
copper(I) bromide in N-methyl-acetamide; methanol; diethyl ether
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 0.5 h; HeatingIrradiation;
参考文献
Ghera, E.; Plemenitas, A.; Ben-David, Y.
Synthesis, 1984 , # 6 p. 504 - 506
反应条件
potassium carbonate in acetone 19 h; Heating;
参考文献
Shishido; Yamashita; Hiroya; Fukumoto; Kametani
Tetrahedron, 1989 , vol. 45, # 18 p. 5791 - 5804
反应条件
1: n-bromosuccinimide / azobisisobutyronitrile / CCl4 / Heating; Irradiation 2: 1.) AgNO3, NaHCO3, 2.) triethylamine / 1.) DMSO, room temp, 1 h, 2.) 15 min 3: 72 percent / n-bromosuccinimide / azobisisobutyronitrile / CCl4 / 0.5 h / Heating; Irradiation View Scheme
参考文献
Synthesis, , # 6 p. 504 - 506
反应条件
1: 1.) AgNO3, NaHCO3, 2.) triethylamine / 1.) DMSO, room temp, 1 h, 2.) 15 min 2: 72 percent / n-bromosuccinimide / azobisisobutyronitrile / CCl4 / 0.5 h / Heating; Irradiation View Scheme
参考文献
Synthesis, , # 6 p. 504 - 506
反应条件
sulfuric acid 12 h; Heating;
参考文献
Comins, Daniel L.; Brown, Jack D.
Journal of Organic Chemistry, 1986 , vol. 51, # 19 p. 3566 - 3572
反应条件
1: 64 percent / Br2, aq. NaOH / 0.5 h / 40 °C 2: 73 percent / conc. H2SO4 / 24 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 10 p. 1798 - 1806
反应条件
1: 1N NaOH / CH2Cl2 / 5 h / Ambient temperature 2: 1.) sec-BuLi, N,N,N',N'-tetramethylethylenediamine (TMEDA) / 1.) THF, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h 3: 71 percent / concd. H2SO4 / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 19 p. 3566 - 3572
