3,6,9,12,15-五氧杂十七烷-1,17-二基二-叠氮化物合成路线 （共 7 条）
反应条件
1: With methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0°C; 5.75 h; 2: With sodium azide; sodium hydrogencarbonate in tetrahydrofuran; water pH=8;
参考文献
GE HEALTHCARE LIMITED; BARNETT, DAVID JONATHAN; HENRIKSEN, INGRID; CONSTANTINOU, MARIA; PETTITT, ROGER PAUL
Patent: US2013/209358 A1, 2013 ;
Location in patent: Paragraph 0122; 0123 ;
反应条件
1: hexa(ethylene glycol) With methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0°C; 5.75 h; 2: sodium azide With sodium hydrogencarbonate in water pH=8; 24 h; Heating / reflux;
参考文献
GE HEALTHCARE AS
Patent: WO2008/72976 A2, 2008 ;
Location in patent: Page/Page column 21-22 ;
反应条件
sodium azide in N,N-dimethyl-formamide T=80°C; 24 h;
参考文献
LaFrate, Andrew L.; Carlson, Kathryn E.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3528 - 3535
反应条件
sodium azide in N,N-dimethyl-formamide T=80°C; 6 h;
参考文献
Iyer, Suri S.; Anderson, Aaron S.; Reed, Scott; Swanson, Basil; Schmidt, Juergen G.
Tetrahedron Letters, 2004 , vol. 45, # 22 p. 4285 - 4288
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=0°C; 3.3 h; 2: With sodium azide in N,N-dimethyl-formamide T=60°C; 14 h;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 31 p. 7706 - 7710
反应条件
hydrogenchloride; triphenylphosphine in diethyl ether; water T=20°C; 4 h;
参考文献
AMERSHAM HEALTH AS; GE HEALTHCARE LIMITED
Patent: WO2006/30291 A2, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=20°C; 24 h;
参考文献
LaFrate, Andrew L.; Carlson, Kathryn E.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3528 - 3535
