N-(2-(二乙基氨基)乙基)-5-甲酰基-2,4-二甲基-1H-吡咯-3-甲酰胺合成路线 （共 19 条）
反应条件
pyrrolidine in ethanol T=78°C; 3 h;
参考文献
RANBAXY LABORATORIES LIMITED; Sanwal, Sudhir Singh; Kumar, Saridi Madhava Dileep; Sathyanarayana, Swargam; Thaper, Rajesh Kumar; Prasad, Mohan
Patent: US2013/123511 A1, 2013 ;
Location in patent: Paragraph 0014; 0015; 0016 ;
反应条件
in methanol; acetonitrile T=25 - 30°C; 3 h;
参考文献
GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; PATKAR, Laxmikant Narahari; POKHARKAR, Kiran Shivaji; HUBLIKAR, Mahesh Gorakhnath; BANSODE, Prakash Vishnu
Patent: WO2011/104555 A2, 2011 ;
Location in patent: Page/Page column 25 ;
反应条件
in methanol; acetonitrile T=25 - 30°C; 3 h;
参考文献
GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; PATKAR, Laxmikant Narahari; POKHARKAR, Kiran Shivaji; HUBLIKAR, Mahesh Gorakhnath; BANSODE, Prakash Vishnu
Patent: WO2011/104555 A2, 2011 ;
Location in patent: Page/Page column 27 ;
反应条件
in methanol; acetonitrile T=25 - 30°C; 3 h;
参考文献
GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; PATKAR, Laxmikant Narahari; POKHARKAR, Kiran Shivaji; HUBLIKAR, Mahesh Gorakhnath; BANSODE, Prakash Vishnu
Patent: WO2011/104555 A2, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
1: sodium hydrogensulfite / ethanol; water / 10 - 20 °C 2: acetonitrile; methanol / 3 h / 25 - 30 °C View Scheme
参考文献
SCINOPHARM (KUNSHAN) BIOCHEMICAL TECHNOLOGY CO., LTD.; HENSCHKE, Julian, P.; CHEN, Yung-Fa
Patent: WO2012/58780 A1, 2012 ;
反应条件
1: pyrrolidine / methanol / 5 - 7 h / Reflux 2: ethanol / 2 - 4 h / Reflux View Scheme
参考文献
SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
反应条件
1: 5-Fluoro-1,3-dihydro-2H-indol-2-one With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane in acetonitrile 7 h; Reflux; 2: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylamino-ethyl)-amide With trimethylsilyl trifluoromethanesulfonate in N,N-dimethyl-formamide; acetonitrile T=20 - 60°C; 3 h; Reagent/catalystSolventTemperatureTimeConcentration;
参考文献
SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
Location in patent: Paragraph 0062; 0063; 0064; 0065; 0071; 0085 ;
反应条件
trimethylsilyl trifluoromethanesulfonate in N,N-dimethyl-formamide; acetonitrile Reflux; Product distribution / selectivity;
参考文献
SCINOPHARM TAIWAN, LTD.; Henscheke, Julian P.; Chen, Yung-Fa
Patent: US2013/190512 A1, 2013 ;
Location in patent: Paragraph 0058; 0059; 0066; 0067; 0068; 0069; 0070 ;
反应条件
1: hydrogenchloride / methanol / 2 h / Reflux 2: ammonia / water / 0.5 h View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar Bhaskar; JOHAR, Perminder Singh; SHARMA, Veerender; SANDHU, Harneet
Patent: WO2012/59941 A1, 2012 ;
