1: 4-amino-piperidine; 4-aminopiperidine dihydrochloride in water 0.0833333 h; 2: N-Benzoyl-imidazole With sodium chloride in water 0.5 h; 3: With sodium hydroxide in water chemoselective reaction;

1.1: sodium carbonate / |Reflux; |Inert atmosphere; |Dean-Stark 2.1: 20 °C / |Inert atmosphere; |Dean-Stark 2.2: 50 °C View Scheme

1: sodium carbonate / |Reflux; |Inert atmosphere; |Dean-Stark 2: 20 °C / |Inert atmosphere; |Dean-Stark View Scheme

1: sodium carbonate / |Reflux; |Inert atmosphere; |Dean-Stark 2: 0.5 h / 0 - 20 °C / |Inert atmosphere; |Dean-Stark 3: water / isopropyl alcohol / 50 °C View Scheme

tris(dibenzylideneacetone)dipalladium (0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate in toluene T=85°C; 20 h; Yields of byproduct given;