4-氯-6,7-二甲氧基喹啉合成路线 （共 24 条）
反应条件
trichlorophosphate in toluene T=115°C; 1 h;
参考文献
XI, Ning; WANG, Tingjin; ZENG, Shan; SUN, Mingming; WANG, Kunrui
Patent: WO2013/180949 A1, 2013 ;
Location in patent: Paragraph 0170 ;
反应条件
trichlorophosphate in toluene 1 h; Heating / reflux;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1559715 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
ammonium hydroxide; trichlorophosphate in dichloromethane; acetonitrile
参考文献
US2012/70368 A1, ;
US 20120070368 A1
反应条件
ammonium hydroxide; trichlorophosphate in dichloromethane; acetonitrile
参考文献
US2012/252840 A1, ;
US 20120252840 A1
反应条件
ammonium hydroxide; trichlorophosphate in dichloromethane; water; acetonitrile
参考文献
US2012/252840 A1, ;
US 20120252840 A1
反应条件
1: aq. NaOH / methanol / 1 h / Heating 2: 2.3 g / diphenyl ether / 1 h / 280 °C 3: 85 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 1 h / 120 °C 2: 3.58 g / diphenyl ether / 1 h / 280 °C 3: aq. NaOH / methanol / 1 h / Heating 4: 2.3 g / diphenyl ether / 1 h / 280 °C 5: 85 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 2.3 g / diphenyl ether / 1 h / 280 °C 2: 85 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 3.58 g / diphenyl ether / 1 h / 280 °C 2: aq. NaOH / methanol / 1 h / Heating 3: 2.3 g / diphenyl ether / 1 h / 280 °C 4: 85 percent / POCl3 / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 7 p. 2186 - 2192
反应条件
1.1: NaOMe / 1,2-dimethoxy-ethane / 1.17 h / 20 °C 1.2: 95 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C 2.1: POCl3 / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 5 p. 1359 - 1366
