4-氯-6,7-二甲氧基喹啉合成路线 （共 24 条）
参考文献
Kirin Beer Kabushiki Kaisha
Patent: US6143764 A1, 2000 ;
反应条件
4-(N,N-dimethlyamino)pyridine in 1,2-dichloro-benzene
T=140°C; 2 h;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1548008 A1, 2005 ;
Location in patent: Page/Page column 117 ;
EP 1548008 A1
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine / chlorobenzene / 100 °C
2.1: lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl / tetrahydrofuran / 2 h / 65 °C
2.2: 0.08 h / 20 °C
View Scheme
参考文献
Kyowa Hakko Kirin Co., Ltd.; FURUTA, Takayuki; KUBO, Kazuo; ATSUMI, Toshiyuki; YAMANOUCHI, Maasa
Patent: EP2594566 A1, 2013 ;
反应条件
in chlorobenzene
Heating / reflux;
参考文献
KIRIN BEER KABUSHIKI KAISHA
Patent: EP1447405 A1, 2004 ;
Location in patent: Page 27-28 ;
EP 1447405 A1
