2-(6-甲基吡啶-2-基)-1-(喹噁啉-6-基)乙酮合成路线 （共 3 条）
反应条件
1: 2,6-dimethylpyridine With n-butyllithium in tetrahydrofuran; hexane T=-60°C; 0.5 h; 2: With diethylaluminium chloride in tetrahydrofuran; hexane T=-60 - 20°C; 3: quinoxaline-6-carbonyl chloride in tetrahydrofuran; hexane T=-60°C; 0.333333 h; Further stages.;
参考文献
Kim, Dae-Kee; Jung, Sun Hee; Lee, Ho Soon; Dewang, Purushottam M.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 568 - 576
反应条件
aq. HBr in dimethyl sulfoxide
参考文献
Gaster, Laramie Mary; Harling, John David
Patent: US2003/149277 A1, 2003 ;
反应条件
1: 66 percent / DMSO; aq. HBr / 2 h / 60 - 70 °C
2: 83 percent / various solvent(s); methanol; H2O / 3 h / 20 °C
View Scheme
参考文献
Kim, Dae-Kee; Jang, Yoojeung; Ho, Soon Lee; Park, Hyun-Ju; Yoo, Jakyung
Journal of Medicinal Chemistry, 2007 , vol. 50, # 13 p. 3143 - 3147
