1: With 4-methyl-morpholine; hydroxylamine Wang resin; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate in N,N-dimethyl-formamide 0.5 h; 2: With piperidine in N,N-dimethyl-formamide 0.166667 h; 3: With trifluoroacetic acid in dichloromethane T=20°C; 0.5 h; Further stages.;
参考文献
Gu, Xianfeng; Wang, Yuehao; Kumar, Anil; Ye, Guofeng; Parang, Keykavous; Sun, Gongqin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7532 - 7539
Mehta, Manish A.; Eddy, Matthew T.; McNeill, Seth A.; Mills, Frank D.; Long, Joanna R.
Journal of the American Chemical Society, 2008 , vol. 130, # 7 p. 2202 - 2212
1: Fmoc-L-phenylalanine With 4-methyl-morpholine; isobutyl chloroformate in tetrahydrofuran T=-15°C; 0.0833333 h; 2: diazomethane in tetrahydrofuran; diethyl ether T=-15 - 20°C; 0.5 h; Further stages.;
参考文献
Glenn, Matthew P.; Kelso, Michael J.; Tyndall, Joel D. A.; Fairlie, David P.
Journal of the American Chemical Society, 2003 , vol. 125, # 3 p. 640 - 641
