[2-(3,4-二氯苯基)-2-羟基乙基]氯化铵合成路线 （共 6 条）
反应条件
1: aq. AcOH; NaOH / ethanol 2: imidazole / CH2Cl2 3: H2 / Raney nickel / methanol 4: Bu4NF / tetrahydrofuran View Scheme
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2009/105220 A1, 2009 ;
WO 2009/105220 A1
反应条件
1: AlCl3 2: ethanol; diethyl ether; ethanolic sodium ethylate / anschliessend Behandeln mit Amylnitrit 3: ethanol; tin (II)-chloride; tin / weiteres Reagens: wss. Salzsaeure 4: amalgam. aluminium; water View Scheme
参考文献
Bercher; Ehlers; Grisk
Pharmazie, 1976 , vol. 31, # 6 p. 351 - 354
参考文献
Bercher; Ehlers; Grisk
Pharmazie, 1976 , vol. 31, # 6 p. 351 - 354
反应条件
1: NaBH4 / methanol / Heating 2: NH3 / ethanol View Scheme
参考文献
Bercher; Ehlers; Grisk
Pharmazie, 1976 , vol. 31, # 6 p. 351 - 354
反应条件
1: ethanol; tin (II)-chloride; tin / weiteres Reagens: wss. Salzsaeure 2: amalgam. aluminium; water View Scheme
参考文献
Glynn; Linnell
Quarterly Journal of Pharmacy and Pharmacology, 1932 , vol. 5, p. 500
Chem. Zentralbl., 1933 , vol. 104, # I p. 605
反应条件
1: ethanol; diethyl ether; ethanolic sodium ethylate / anschliessend Behandeln mit Amylnitrit 2: ethanol; tin (II)-chloride; tin / weiteres Reagens: wss. Salzsaeure 3: amalgam. aluminium; water View Scheme
参考文献
Glynn; Linnell
Quarterly Journal of Pharmacy and Pharmacology, 1932 , vol. 5, p. 500
Chem. Zentralbl., 1933 , vol. 104, # I p. 605
