3-甲基-4-硝基苯甲酰氯合成路线 （共 4 条）
参考文献
Robertson; Beedle; Wilson; Parli; Smallwood; Steinberg
Journal of Medicinal Chemistry, 1988 , vol. 31, # 7 p. 1290 - 1295
反应条件
1: 65 percent / pyridine / 1 h / Heating 2: 86 percent / Lawesson's reagent; HMPA / 15 h / 100 °C 3: 87 percent / NaH / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C 4: 54 percent / SnCl2*2H2O / ethanol / 2 h / Heating View Scheme
参考文献
Hutchinson; Chua; Browne; Trapani; Bradshaw; Westwell; Stevens
Journal of Medicinal Chemistry, 2001 , vol. 44, # 9 p. 1446 - 1455
反应条件
ammonia in ethylene glycol dimethyl ether; water T=10 - 15°C;
参考文献
WO2008/88927 A1, ;
Page/Page column 26-27 ;
WO 2008/088927 A1
反应条件
1: diethyl ether / 3 h / Ambient temperature 2: Ag2O, aq. Na2S2O3 / dioxane / 3 h / 75 - 80 °C View Scheme
参考文献
Dodic, Nerina; Dumaitre, Bernard; Daugan, Alain; Pianetti, Pascal
Journal of Medicinal Chemistry, 1995 , vol. 38, # 13 p. 2418 - 2426
