N-Cbz-L-高丝氨酸内酯合成路线 (共 19 条)
反应条件
1: NaHCO3 / dioxane; H2O 2: acetic acid; formic acid 3: H2O / 100 °C / pH 7 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 1 p. 50 - 54
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=23°C; 16 h;
参考文献
Ozinskas; Rosenthal
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5047 - 5050
反应条件
trifluoroacetic acid in dichloromethane 0.5 h; Ambient temperature;
参考文献
Easmon; Heinisch; Holzer; Matuszczak
Archiv der Pharmazie, 1995 , vol. 328, # 4 p. 367 - 370
反应条件
triethylamine in dichloromethane T=0°C; 3 h;
参考文献
Lall, Manjinder S.; Karvellas, Constantine; Vederas, John C.
Organic Letters, 1999 , vol. 1, # 5 p. 803 - 806
反应条件
hydrogen; tris(triphenylphosphine)ruthenium(II) chloride in benzene P=7600 Torr;
参考文献
Tetrahedron Letters, , vol. 33, # 19 p. 2669 - 2672
反应条件
1: 84 percent / NaIO4 2: 20 percent / 1,2-dichloro-benzene / 160 °C 3: dioxane / 85 °C 4: H2O2; NaOH View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 2 p. 544 - 553
反应条件
1: dioxane / 85 °C 2: H2O2; NaOH View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 2 p. 544 - 553
反应条件
1: 20 percent / 1,2-dichloro-benzene / 160 °C 2: dioxane / 85 °C 3: H2O2; NaOH View Scheme
参考文献
Chemistry - A European Journal, , vol. 10, # 2 p. 544 - 553
反应条件
1: Ca(BH4)2; t-BuOK / ethanol / 17 h / -10 - 25 °C 2: 38.3 g / conc. HCl / ethanol View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 5 p. 1298 - 1304
反应条件
2-iodo-acetamide; citric acid 1.) ethanol, water, 45 deg C, 72 h, 2.) ethanol, water, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 51, # 26 p. 5047 - 5050