6-羧基-4-苯基-3,4-二氢香豆素合成路线 （共 4 条）
反应条件
sulfuric acid; acetic acid in water T=100°C; 18 h;
参考文献
SCHWARZ PHARMA AG
Patent: WO2007/144097 A1, 2007 ;
Location in patent: Page/Page column 16-17 ;
反应条件
sulfuric acid; acetic acid T=100°C; 16 h;
参考文献
WO2012/98560 A2, ;
Page/Page column 67 ;
WO 2012/098560 A2
反应条件
1: acetone / 2 h / 25 - 35 °C 2: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -20 °C 3: hydrogen / 5 palladium on charcoal / methanol / 18 h / 25 - 35 °C / 2942.29 Torr / autoclave 4: potassium carbonate / acetone / 6 h / Reflux View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; RAGHURAM, Suraparaju; SEETHA RAMA SARMA, Peri
Patent: WO2012/98560 A2, 2012 ;
WO 2012/098560 A2
反应条件
1: acetone / 2 h / 25 - 35 °C 2: boron trifluoride diethyl etherate / tetrahydrofuran / 1 h / -20 °C 3: hydrogen / 5 palladium on charcoal / methanol / 18 h / 25 - 35 °C / 2942.29 Torr / autoclave 4: potassium carbonate / acetone / 6 h / Reflux 5: sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 5 °C / Inert atmosphere View Scheme
参考文献
WO2012/98560 A2, ;
WO 2012/098560 A2
