1-(2-丙基)-2-苯并咪唑啉酮合成路线 （共 7 条）
反应条件
in tetrahydrofuran 20 h; Ambient temperature;
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
1: 80 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C 2: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C View Scheme
参考文献
Yu, Kuo-Long; Wang, Xiangdong; Sun, Yaxiong; Cianci, Christopher; Thuring, Jan Willem; Combrink, Keith; Meanwell, Nicholas; Zhang, Yi; Civiello, Rita L.
Patent: US2003/207868 A1, 2003 ;
反应条件
hydrogenchloride in water T=60°C; 1 h;
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
反应条件
potassium hydroxide; [bis(acetoxy)iodo]benzene in methanol T=0°C; 1 h;
参考文献
Prakash; Batra; Kaur; Sharma; Singh; Moriarty
Synthesis, 2001 , # 4 p. 541 - 543
反应条件
1: 83 percent / H2 / 10 percent Pd/C / ethanol / 16 h / 20 °C / 2280 Torr 2: 46 percent / tetrahydrofuran / 20 h / Ambient temperature View Scheme
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
1: 1.) TFA, 2.) BH3*pyridine / 1.) toluene, RT, 1 h, 2.) toluene, 20 h 2: 83 percent / H2 / 10 percent Pd/C / ethanol / 16 h / 20 °C / 2280 Torr 3: 46 percent / tetrahydrofuran / 20 h / Ambient temperature View Scheme
参考文献
Tapia, Ines; Alonso-Cires, Luisa; Lopez-Tudanca, Pedro Luis; Mosquera, Ramon; Labeaga, Luis; Innerarity, Ana; Orjales, Aurelio
Journal of Medicinal Chemistry, 1999 , vol. 42, # 15 p. 2870 - 2880
反应条件
1: 75 percent / 0.08 h / 150 °C 2: 80 percent / 50percent aq. NaOH / triethylbutylammonium chloride / benzene / 1 h / 60 °C 3: 95 percent / conc. hydrochloric acid / H2O / 1 h / 60 °C View Scheme
参考文献
Vernin, Gaston; Domlog, Hicham; Siv, Chan; Metzger, Jaques; El-Shafei, Ahmed Kamal
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 85 - 89
