(S)-3-羟基十四烷酸合成路线 （共 28 条）
反应条件
1: CuI / toluene; tetrahydrofuran / 5 h / 5 - 8 °C 2: aq. NaOH / toluene; methanol / 4.5 h / 20 °C 3: H2SO4 / methanol; H2O / 1.8 h / 48 - 52 °C / pH 10.8-12.2 4: aq. H2O2; aq. NaOH / methanol / 10 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 15 p. 2945 - 2950
反应条件
1: H2SO4 / methanol; H2O / 1.8 h / 48 - 52 °C / pH 10.8-12.2 2: aq. H2O2; aq. NaOH / methanol / 10 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 15 p. 2945 - 2950
反应条件
1: aq. NaOH / toluene; methanol / 4.5 h / 20 °C 2: H2SO4 / methanol; H2O / 1.8 h / 48 - 52 °C / pH 10.8-12.2 3: aq. H2O2; aq. NaOH / methanol / 10 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 10, # 15 p. 2945 - 2950
反应条件
1: 1.4 eq. R-Alpine-Borane / neat (no solvent) / 8 h / 0 - 20 °C 2: 1) 2.4 eq. n-BuLi; 2) 1.4 M H2SO4 / 1) THF, -78 deg C; 2) from -20 deg C to room temperature 3: 1) 2 eq. dicyclohexylborane; 2) NaOH, H2O2 / 1) THF, 0 deg C; 2) 40-50 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 14 p. 1833 - 1836
反应条件
1: 1) 2.4 eq. n-BuLi; 2) 1.4 M H2SO4 / 1) THF, -78 deg C; 2) from -20 deg C to room temperature 2: 1) 2 eq. dicyclohexylborane; 2) NaOH, H2O2 / 1) THF, 0 deg C; 2) 40-50 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 30, # 14 p. 1833 - 1836
反应条件
sodium hydroxide; bis(cyclohexanyl)borane; dihydrogen peroxide 1) THF, 0 deg C; 2) 40-50 deg C; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 30, # 14 p. 1833 - 1836
参考文献
Chemical and pharmaceutical bulletin, , vol. 19, # 7 p. 1308 - 1314
参考文献
Kikukawa, Tadashi; Tai, Akira
Chemistry Letters, 1984 , p. 1935 - 1936
