3-(1H-吲哚-3-基)-丁酸合成路线 （共 5 条）
反应条件
potassium hydroxide 5 h; Heating;
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RAO, Jagannath Madanahalli Ranganath; VENKATESHAM, Uppala; DOPPALAPUDI, Sivanageswara Rao; KENCHEGOWDA, Bommegowda Yadaganahalli; FERNAND, George; GEORGE, Jenson; MADHAVAN, G R; NAIDU, Gorle Paidapu; KADAMBARI, V. S. Naga Rajesh; JAGANNATH, S; MANIVANNAN, R; KUMAR, T Senthil; KUMAR, B Siva Senthil; MALLIKARJUNA, Rayi
Patent: WO2013/111150 A1, 2013 ;
Location in patent: Page/Page column 96 ;
反应条件
hydrogenchloride; sodium dihydrogenphosphate; NaClO2 in water; tert-butyl alcohol
参考文献
MacMillan, David W.C.
Patent: US2003/109718 A1, 2003 ;
反应条件
C72H61O4P in toluene T=-10°C; Friedel Crafts alkylation; 72 h; Inert atmosphere; enantioselective reaction;
参考文献
Bachu, Prabhakar; Akiyama, Takahiko
Chemical Communications, 2010 , vol. 46, # 23 p. 4112 - 4114
反应条件
sodium hydroxide; copper 1.) 5 h, reflux, pyridine/C2H5OH, 2.) 2 h, reflux, C2H5OH; Yield given. Multistep reaction;
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RAO, Jagannath Madanahalli Ranganath; VENKATESHAM, Uppala; DOPPALAPUDI, Sivanageswara Rao; KENCHEGOWDA, Bommegowda Yadaganahalli; FERNAND, George; GEORGE, Jenson; MADHAVAN, G R; NAIDU, Gorle Paidapu; KADAMBARI, V. S. Naga Rajesh; JAGANNATH, S; MANIVANNAN, R; KUMAR, T Senthil; KUMAR, B Siva Senthil; MALLIKARJUNA, Rayi
Patent: WO2013/111150 A1, 2013 ;
反应条件
1: acetonitrile / 20 °C 2: copper; pyridine / 3 h / 110 °C 3: potassium hydroxide; water / methanol / 3 h / 70 °C View Scheme
参考文献
Kononova, V. V.; Semenov, A. A.; Kirdei, E. G.; Fedoseev, A. P.; Bulavintsev, A. G.; Nechaev, V. I.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 1 p. 36 - 39
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 1 p. 60 - 63
