2,3-二氢苯并呋喃-7-羧酸合成路线 （共 29 条）
反应条件
1: 99.8 percent / 15 h / Heating 2: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h 3: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl 4: SOCl2 5: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 6: 57 percent / NaBH4 / ethanol / 3 h 7: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 8: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: SOCl2 2: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 3: 57 percent / NaBH4 / ethanol / 3 h 4: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 5: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl 2: SOCl2 3: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 4: 57 percent / NaBH4 / ethanol / 3 h 5: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 6: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 2: 57 percent / NaBH4 / ethanol / 3 h 3: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 4: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: 57 percent / NaBH4 / ethanol / 3 h 2: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 3: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 2: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: NaH / 1) 20 min at 0 deg C 2) reflux for 12 h 2: NaOH / 1) 1h reflux with NaOH 2) concentrated HCl 3: SOCl2 4: 1) ozone 2) dimethyl sulfide / 1) 3 in MeOH at -78 deg C 2) room temperature overnight 5: 57 percent / NaBH4 / ethanol / 3 h 6: 82 percent / NaH / tetrahydrofuran / 24.5 h / Heating 7: 49 percent / 4.5M HCl / H2O / 24 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 4 p. 783 - 788
反应条件
1: 79 percent / sodium acetate, bromine / acetic acid / 3 h / 80 °C 2: dimethylformamide, thionyl chloride / toluene / 1 h / 65 °C View Scheme
参考文献
Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309
反应条件
1: SOCl2 / toluene / 3 h / Heating 3: 64 percent / 2,3-dichlor-5,6-dicyano-1,4-benzochinon / 4 h / Heating 4: 90 percent / KOH / methanol; H2O / 3 h / Heating View Scheme
参考文献
Stanetty, Peter; Puerstinger, Gerhard
Journal of Chemical Research, Miniprint, 1991 , # 3 p. 581 - 594
反应条件
bromine; sodium acetate in acetic acid T=80°C; 3 h;
参考文献
Hogberg; De Paulis; Johansson; Kumar; Hall; Ogren
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2305 - 2309
