4-溴-2,5-二氟-苯甲醛合成路线 （共 4 条）
反应条件
1: 1.4-dibromo-2,5-difluorobenzene With n-butyllithium in toluene T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in toluene T=-78 - 20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; FELL, Jay Bradford; FISCHER, John P.; HINKLIN, Ronald J.
Patent: WO2013/74641 A1, 2013 ;
Location in patent: Paragraph 00350 ;
反应条件
ammonium chloride in tetrahydrofuran; N,N-dimethyl-formamide
参考文献
ASTRAZENECA AB
Patent: US2010/267723 A1, 2010 ;
参考文献
Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Mete, Antonio; Pimm, Austen
Patent: US2003/158185 A1, 2003 ;
参考文献
Cheshire, David; Connolly, Stephen; Cox, David; Hamley, Peter; Mete, Antonio; Pimm, Austen
Patent: US2003/158185 A1, 2003 ;
