1,3,4,5-四氢-1,5-亚甲基-2H-3-苯骈吖庚因-2-酮合成路线 （共 8 条）
反应条件
1: With hydrogen; toluene-4-sulfonic acid; palladium hydroxide - carbon; water in methanol T=50°C; P=2585.74 Torr; 24 h; 2: With sodium t-butanolate in methanol 2 h; Heating;
参考文献
O'Donnell, Christopher J.; Singer, Robert A.; Brubaker, Jason D.; McKinley, Jason D.
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5756 - 5759
反应条件
sodium methylate in methanol
参考文献
Pfizer Inc
Patent: US6605610 B1, 2003 ;
反应条件
sodium hydrogencarbonate; sodium t-butanolate in methanol; ethyl acetate; toluene
参考文献
Singer, Robert A.
Patent: US2003/60624 A1, 2003 ;
反应条件
1: With sulfuric acid; hydrogen; palladium on activated charcoal in methanol 2: With sodium t-butanolate in isopropyl alcohol
参考文献
Singer, Robert A.; McKinley, Jason D.; Barbe, Guillaume; Farlow, Robin A.
Organic Letters, 2004 , vol. 6, # 14 p. 2357 - 2360
反应条件
1.1: 75 percent / P(Cy)3; t-BuONa / Pd(OAc)2 / 1,2-dimethoxy-ethane / 22 h / 60 °C 2.1: H2; H2SO4 / Pd/C / methanol 2.2: t-BuONa / propan-2-ol View Scheme
参考文献
Singer, Robert A.; McKinley, Jason D.; Barbe, Guillaume; Farlow, Robin A.
Organic Letters, 2004 , vol. 6, # 14 p. 2357 - 2360
反应条件
1.1: P(Cy)3; t-BuONa / Pd(OAc)2 / tetrahydrofuran / 2.5 h / 60 °C 1.2: 77 percent / aq. H2SO4 / tetrahydrofuran / 15 h / 20 °C 2.1: H2; H2SO4 / Pd/C / methanol 2.2: t-BuONa / propan-2-ol View Scheme
参考文献
Singer, Robert A.; McKinley, Jason D.; Barbe, Guillaume; Farlow, Robin A.
Organic Letters, 2004 , vol. 6, # 14 p. 2357 - 2360
反应条件
1.1: 96 percent / H2SO4 / 4 h / Heating 2.1: 97 percent / ZnI2 / toluene; acetonitrile / 5 h / 50 °C 3.1: TsOH*H2O; hydrogen / Pearlman's catalyst Pd(OH)2/C/H2O / methanol / 24 h / 50 °C / 2585.74 Torr 3.2: 51 percent / NaOtBu / methanol / 2 h / Heating View Scheme
参考文献
O'Donnell, Christopher J.; Singer, Robert A.; Brubaker, Jason D.; McKinley, Jason D.
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5756 - 5759
反应条件
1.1: 97 percent / ZnI2 / toluene; acetonitrile / 5 h / 50 °C 2.1: TsOH*H2O; hydrogen / Pearlman's catalyst Pd(OH)2/C/H2O / methanol / 24 h / 50 °C / 2585.74 Torr 2.2: 51 percent / NaOtBu / methanol / 2 h / Heating View Scheme
参考文献
O'Donnell, Christopher J.; Singer, Robert A.; Brubaker, Jason D.; McKinley, Jason D.
Journal of Organic Chemistry, 2004 , vol. 69, # 17 p. 5756 - 5759
