3-氨基-2-羟基苯甲酸甲酯合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated carbon in methanol T=20°C; P=3102.97 Torr; 49 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/63155 A1, 2004 ;
Location in patent: Page 172 ;
WO 2004/063155 A1
反应条件
sodium acetate in water; ethyl acetate T=25°C; P=760.051 Torr; 16 h;
参考文献
LEAD THERAPEUTICS, INC.
Patent: US2009/197863 A1, 2009 ;
Location in patent: Page/Page column 56 ;
反应条件
sulfuric acid T=0 - 70°C; 12 h; Inert atmosphere;
参考文献
AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.
Patent: WO2011/72174 A1, 2011 ;
Location in patent: Page/Page column 146-147 ;
WO 2011/072174 A1
参考文献
Justus Liebigs Annalen der Chemie, , vol. 311, p. 55
反应条件
in methanol; water; acetic acid
参考文献
Pfizer Inc
Patent: US6166011 A1, 2000 ;
反应条件
(i) HCl, Et2O, EtOAc, (ii) aq. K3<Fe(CN)6>, KH2PO4, NaOH; Multistep reaction;
参考文献
Wu,M.T.; Lyle,R.E.
Journal of Heterocyclic Chemistry, 1971 , vol. 8, p. 989 - 991
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Huxley, Anthony
Synlett, 2006 , # 16 p. 2658 - 2660
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Huxley, Anthony
Synlett, 2006 , # 16 p. 2658 - 2660
反应条件
pyridinium p-toluenesulfonate; triethylamine in xylene
Heating;
参考文献
Huxley, Anthony
Synlett, 2006 , # 16 p. 2658 - 2660
反应条件
pyridinium p-toluenesulfonate; triethylamine in xylene
Heating;
参考文献
Huxley, Anthony
Synlett, 2006 , # 16 p. 2658 - 2660
