(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸合成路线 （共 11 条）
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
[Pt(en)2Cl2](2+); ethylenediaminetetraacetic acid; sodium chloride in phosphate buffer pH=7.3;
参考文献
Shi, Tiesheng; Rabenstein, Dallas L.
Journal of the American Chemical Society, 2000 , vol. 122, # 29 p. 6809 - 6815
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 54 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 1 h / Ambient temperature; pH 10 2: 62 percent / ferric chloride / dioxane; H2O / 0.5 h / 35 °C 3: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7 4: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 5: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 74 percent / 1 M NaOH / dioxane / 3 h / Ambient temperature 2: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7 3: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 4: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 60 percent / CaCl2, thermolysin / dimethylformamide; various solvent(s) / 24 h / 38 °C / pH 7.0 2: 74 percent / 1 M NaOH / dioxane / 3 h / Ambient temperature 3: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7 4: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 5: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 62 percent / ferric chloride / dioxane; H2O / 0.5 h / 35 °C 2: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7 3: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 4: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 64 percent / α-chymotrypsin / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 7 2: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 3: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 34 percent / ethylenediaminetetraacetic acid, cysteine hydrochloride, papain / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 4.8 2: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 3: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 64 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 2: 34 percent / ethylenediaminetetraacetic acid, cysteine hydrochloride, papain / dimethylformamide; various solvent(s) / 20 h / 38 °C / pH 4.8 3: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 4: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
1: 59 percent / ferric chloride / dimethylformamide; H2O / 0.5 h / 35 °C 2: 1.) Na/NH3, 2.) NH4Cl, 3.) trifluoroacetic acid, O2 View Scheme
参考文献
Cerovsky, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 6 p. 1352 - 1360
→
35748-51-7(4R,7S,10S,16S,19R)-19-氨基-7-(2-氨基-2-氧代乙基)-10-(3-氨基-3-氧代丙基)-16-[(4-羟基苯基)甲基]-6,9,12,15,18-五氧代-13-(苯基甲基)-1,2-二硫杂-5,8,11,14,17-五氮杂环二十烷-4-羧酸
反应条件
(i) Na, aq. NH3, (ii) O2, CF3CO2H; Multistep reaction;
参考文献
Ferger,M.F. et al.
Journal of the American Chemical Society, 1972 , vol. 94, p. 982 - 984
