3-氨基-N-Cbz-L-丙氨酸合成路线 （共 27 条）
反应条件
[bis(acetoxy)iodo]benzene in water; ethyl acetate; acetonitrile T=20°C; Hoffmann rearrangement; 4 h;
参考文献
Dobrovinskaya, Nina A.; Archer; Hulme, Alison N.
Synlett, 2008 , # 4 p. 513 - 516
反应条件
Et3SiNH2 in acetonitrile T=50°C; 18 h;
参考文献
Ratemi, Elaref S.; Vederas, John C.
Tetrahedron Letters, 1994 , vol. 35, # 41 p. 7605 - 7608
反应条件
hydrogenchloride in 1,4-dioxane 3 h;
参考文献
Noguchi, Noriyoshi; Kuroda, Tsuyoshi; Hatanaka, Minoru; Ishimaru, Toshiyasu
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 2 p. 633 - 634
反应条件
sodium hydroxide in toluene 4.5 h; 0.05 M phosphate buffer (pH 7);
参考文献
Mokotoff; Logue
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 554 - 559
反应条件
1: 89 percent / iodosobenzene diacetate / ethyl acetate; acetonitrile; H2O / 4.5 h / 15 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 67, # 12 p. 4017 - 4029
反应条件
1: diphenyl diphosphorazidate, Et3N / benzene / 15 h 2: benzene / 3 h / Heating 3: 95 percent / NaOH / acetone; H2O / 2 h / 0 - 5 °C 4: 92 percent / 4 M HCl in dioxane / dioxane / 3 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 2 p. 633 - 634
反应条件
1: 95 percent / NaOH / acetone; H2O / 2 h / 0 - 5 °C 2: 92 percent / 4 M HCl in dioxane / dioxane / 3 h View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 2 p. 633 - 634
参考文献
Journal of Medicinal Chemistry, , vol. 19, p. 766 - 772
反应条件
sodium hydroxide; trifluoroacetic acid 2.) CH2Cl2, RT, 60 min; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 554 - 559
反应条件
Yield given. Multistep reaction;
参考文献
Synthesis, , # 2 p. 190 - 192
