2-(三氯甲基)-苯并咪唑合成路线 (共 16 条)
参考文献
Societe L'Oreal S.A.
Patent: US6221343 B1, 2001 ;
反应条件
acetic acid 2 h; Ambient temperature;
参考文献
YALE UNIVERSITY; JORGENSEN, William; BUCALA, Richard, J.
Patent: WO2010/21693 A2, 2010 ;
Location in patent: Page/Page column 38-39 ;
反应条件
acetic acid T=20°C; 1 h;
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
Location in patent: Page/Page column 138 ;
WO 2011/143365 A1
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Porzelle, Achim; Woodrow, Michael D.; Tomkinson, Nicholas C.O.
Organic Letters, 2010 , vol. 12, # 7 p. 1492 - 1495
反应条件
1: hydrogenchloride; iron / ethanol; water / Reflux 2: acetic acid / 20 °C View Scheme
参考文献
Lane, Charlotte A.L.; Hay, Duncan; Mowbray, Charles E.; Paradowski, Michael; Selby, Matthew D.; Swain, Nigel A.; Williams, David H.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1156 - 1159
参考文献
Sinha, Hermant K.; Dogra, Sneh K.
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 8 p. 2668 - 2675
反应条件
triethylamine in ethanol
参考文献
Ennis,B.C. et al.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 33 - 39
反应条件
1: 66 percent / NH3 / -78 deg C, 5 min; -78 deg C to RT 2: 88 percent / NH2OH*HCl, NaOEt / ethanol / 3 h / Heating View Scheme
参考文献
Cundy, Darren J.; Simpson, Gregory W.
Australian Journal of Chemistry, 1996 , vol. 49, # 2 p. 199 - 204
反应条件
1.1: sodium carbonate / 14 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 2.2: 4 h / 20 °C View Scheme
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
WO 2011/143365 A1
反应条件
1: With water; sodium hydroxide T=0°C; 2 h; 2: With hydrogenchloride in water pH=3;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
Patent: US2009/258876 A1, 2009 ;
Location in patent: Page/Page column 9 ;