2,8-双(三氟甲基)-4-羟基喹啉合成路线 （共 10 条）
反应条件
polyphosphoric acid T=150°C;
参考文献
Eswaran, Sumesh; Adhikari, Airody Vasudeva; Chowdhury, Imran H.; Pal, Nishith K.; Thomas
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 8 p. 3374 - 3383
反应条件
phosphorus oxytribromide T=150°C; 6 h; Inert atmosphere;
参考文献
Université de Picardie Jules Verne
Patent: EP2487157 A1, 2012 ;
Location in patent: Page/Page column 12 ;
反应条件
1: 90 percent / NaH / toluene; dimethylformamide / 20 h / 110 °C 2: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature 3: 40 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature View Scheme
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
反应条件
1: 90 percent / NaH / toluene; dimethylformamide / 20 h / 110 °C 2: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature 3: 40 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature 4: 80 percent / H2, HCl / PtO2 / methanol; ethanol / 5.5 h View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
trichlorophosphate T=110°C; 2 h;
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
反应条件
1: phosphorus oxytribromide / 6 h / 150 °C / Inert atmosphere 2: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / acetonitrile / 4 h / 90 °C / Inert atmosphere; Sealed tube View Scheme
参考文献
Jonet, Alexia; Dassonville-Klimpt, Alexandra; Da Nascimento, Sophie; Leger, Jean-Michel; Guillon, Jean; Sonnet, Pascal
Tetrahedron Asymmetry, 2011 , vol. 22, # 2 p. 138 - 148
反应条件
1: sodium hydroxide / acetone / 1 h / 10 °C / pH 7.5 / |Inert atmosphere 2: P4; iodine; acetic acid / acetic acid / 10 h / 10 - 20 °C / |Inert atmosphere View Scheme
参考文献
Meshram, H. M.; Chennakesava Reddy, B.; Aravind Kumar, D.; Kalyan, M.; Ramesh, P.; Kavitha, P.; Venkateswara Rao, J.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012 , vol. 51, # 9 p. 1411 - 1416,6
反应条件
1: 90 percent / NaH / toluene; dimethylformamide / 20 h / 110 °C
2: 0.5 g / BuLi / tetrahydrofuran; hexane / Ambient temperature
3: 45 percent / TBAF / acetonitrile / 0.17 h / Ambient temperature
View Scheme
参考文献
Adam
Tetrahedron, 1989 , vol. 45, # 5 p. 1409 - 1414
反应条件
1: 85 percent / POCl3 / 2 h / 110 °C
2: 1.) NaH / 1.) toluene, DMF, 0 - 5 deg C, 1 h, 2.) toluene, DMF, 5 - 10 deg C, 2 h
View Scheme
参考文献
Adam, Solange
Tetrahedron, 1991 , vol. 47, # 36 p. 7609 - 7614
反应条件
1: phosphorus oxytribromide / 6 h / 150 °C / Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; potassium carbonate / acetonitrile / 4 h / 90 °C / Inert atmosphere; Sealed tube
3: MnIII(L-3,5-t-Bu)(Cl); 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid / -78 °C
View Scheme
参考文献
Jonet, Alexia; Dassonville-Klimpt, Alexandra; Da Nascimento, Sophie; Leger, Jean-Michel; Guillon, Jean; Sonnet, Pascal
Tetrahedron Asymmetry, 2011 , vol. 22, # 2 p. 138 - 148
