2-(3-甲氧基苄基)吡啶合成路线 （共 10 条）
反应条件
palladium diacetate; tris-(o-tolyl)phosphine in toluene T=60°C; 10 h; Inert atmosphere;
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
potassium phosphate; C12H10ClNPd*C16H21O3P in tetrahydrofuran; water T=60°C; 20 h;
参考文献
Schmink, Jason R.; Tudge, Matthew T.
Tetrahedron Letters, 2013 , vol. 54, # 1 p. 15 - 20
反应条件
palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine in o-xylene; toluene 6 h; Inert atmosphereReflux;
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
1: 60 percent / sodium hydride / toluene / 6 h / 120 °C 2: 1.) potassium hydroxide; 2.) 85percent H3PO4 / 1.) ethanol, water, 100 deg C; 2.) water, 115 deg C View Scheme
参考文献
Cardellini; Claudi; Perlini; Balduini; Cattabeni; Cimino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 4 p. 307 - 317
反应条件
1: 60 percent / sodium hydride / toluene / 6 h / 120 °C 2: 1.) potassium hydroxide; 2.) 85percent H3PO4 / 1.) ethanol, water, 100 deg C; 2.) water, 115 deg C View Scheme
参考文献
Cardellini; Claudi; Perlini; Balduini; Cattabeni; Cimino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 4 p. 307 - 317
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -50 °C / Inert atmosphere 1.2: 2 h / -50 °C / Inert atmosphere 1.3: Inert atmosphere 2.1: palladium (II) trifluoroacetate; caesium carbonate; tri-cyclo-hexyl-phosphine / o-xylene; toluene / 6 h / Inert atmosphere; Reflux View Scheme
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
反应条件
1: n-butyllithium / hexane / 3.02 h / -78 °C 2: palladium diacetate; tris-(o-tolyl)phosphine / toluene / 10 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Chen, Xu; Zhou, Lingmin; Li, Yimei; Xie, Tao; Zhou, Shuangliu
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 230 - 239
反应条件
potassium hydroxide; phosphoric acid 1.) ethanol, water, 100 deg C; 2.) water, 115 deg C; Yield given. Multistep reaction;
参考文献
Cardellini; Claudi; Perlini; Balduini; Cattabeni; Cimino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 4 p. 307 - 317
反应条件
hydrogen; platinum(IV) oxide in acetic acid T=20°C; P=1551.4 Torr; 10 h;
参考文献
Cardellini; Claudi; Perlini; Balduini; Cattabeni; Cimino
Farmaco, Edizione Scientifica, 1987 , vol. 42, # 4 p. 307 - 317
反应条件
ferrous chloride tetrahydrate; oxygen; acetic acid in dimethyl sulfoxide
T=100°C; 24 h;
参考文献
De Houwer, Johan; Abbaspour Tehrani, Kourosch; Maes, Bert U. W.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2745 - 2748
