顺式-四氢-1H-环戊并[c]呋喃-1,3(3aH)-二酮合成路线 （共 14 条）
反应条件
1: quinine / toluene; CCl4 / 60 h / -55 °C 2: triethylamine / tetrahydrofuran / 1 h / -20 °C 3: NaN3 / tetrahydrofuran; H2O / -10 - 20 °C 4: benzene / 2 h / Heating 5: triethylamine / CH2Cl2 / 4 h / Heating 6: 98 percent / H2 / Pd/C / methanol / 20 °C View Scheme
参考文献
Zhang, Mingbao; Zhu, Lei; Ma, Xin
Tetrahedron: Asymmetry, 2003 , vol. 14, # 22 p. 3455 - 3468
参考文献
Mohr, Peter; Waespe-Sarcevic, Nada; Tamm, Christoph; Gawronska, Krystyna; Gawronsky, Jacek K.
Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2501 - 2511
反应条件
(i) MeOH, (ii) LiAlH4, THF; Multistep reaction;
参考文献
Allinger,N.L.; Zalkow,V.B.
Journal of the American Chemical Society, 1961 , vol. 83, p. 1144 - 1146
View citing articles Show Details
Jakovac, Ignac J.; Goodbrand, H. Bruce; Lok, Kar P.; Jones, J. Bryan
Journal of the American Chemical Society, 1982 , vol. 104, # 17 p. 4659 - 4665
Title/Abstract View citing articles Show Details
Shimizu, Hideki; Onitsuka, Satoaki; Egami, Hiromichi; Katsuki, Tsutomu
Journal of the American Chemical Society, 2005 , vol. 127, # 15 p. 5396 - 5413
反应条件
1: 24 h / 60 °C / |Inert atmosphere
2: lithium diisopropyl amide / 4 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
