2-(1,3-二氧代异吲哚啉-2-基)-3-苯基丙酸合成路线 （共 13 条）
反应条件
T=150°C; P=40 Torr; 0.833333 h;
参考文献
Zhao, Rong; Guo, Peijiang; Dong, Junyu; Zhang, Xiaoping; Sun, Xiaofei; Tian, Yun; Zeng, Qingle
Organic Preparations and Procedures International, 2011 , vol. 43, # 4 p. 377 - 380
反应条件
sodium carbonate in water
参考文献
Celgene Corporation
Patent: US5698579 A1, 1997 ;
反应条件
in water T=20°C; 3 h;
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
参考文献
Pfaehler
Chemische Berichte, 1913 , vol. 46, p. 1701
反应条件
1: SOCl2; DMF / 20 °C 2: diethyl ether; toluene / 0 °C 3: 77 percent / PhCO2Ag; Et3N / 2 h / Heating 4: LiBH4 / tetrahydrofuran; H2O / 1 h 5: AcOH / 80 °C View Scheme
参考文献
Achmatowicz, Michal; Szumna, Agnieszka; Zielinski, Tomasz; Jurczak, Janusz
Tetrahedron, 2005 , vol. 61, # 38 p. 9031 - 9041
反应条件
1: DMAP; DCC / CH2Cl2 / 15 h / 25 °C 2: acid View Scheme
参考文献
Calmes, Monique; Glot, Christele; Michel, Thibaut; Rolland, Marc; Martinez, Jean
Tetrahedron Asymmetry, 2000 , vol. 11, # 3 p. 737 - 741
反应条件
potassium hydroxide in diethyl ether; water
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
反应条件
1: benzene; phosphorus (V)-chloride
2: tetrachloromethane
View Scheme
参考文献
Pracejus
Justus Liebigs Annalen der Chemie, 1959 , vol. 622, p. 10,21
反应条件
propionic acid potassium salt in water; acetone
24 h; Irradiation;
参考文献
Oelgemoeller, Michael; Cygon, Peter; Lex, Johann; Griesbeck, Axel G.
Heterocycles, 2003 , vol. 59, # 2 p. 669 - 684
反应条件
acrylic acid methyl ester in acetonitrile
6 h; Irradiation;
参考文献
Yoon, Ung Chan; Kim, Dong Uk; Lee, Chan Woo; Choi, Young Sun; Lee, Yean-Jang; Ammon, Herman L.; Mariano, Patrick S.
Journal of the American Chemical Society, 1995 , vol. 117, # 10 p. 2698 - 2710
