2,3,4,5-四甲氧基甲苯合成路线 （共 45 条）
反应条件
1: Zn, HCl 2: H2O / Heating 3: 69 percent / NaOH 4: 1.) n-BuLi, TMEDA / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, 0 deg C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 15 p. 3799 - 3800
反应条件
1: 69 percent / NaOH 2: 1.) n-BuLi, TMEDA / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, 0 deg C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 15 p. 3799 - 3800
反应条件
1: H2O / Heating 2: 69 percent / NaOH 3: 1.) n-BuLi, TMEDA / 1.) THF, hexane, 0 deg C, 2.) THF, hexane, 0 deg C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 121, # 15 p. 3799 - 3800
反应条件
1: 1.) 75percent H2O2,trifluoroacetic anhydride, 2.) KOH / 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min 2: 97 percent / K2CO3 / acetone / 22 h / Heating 3: 92 percent / Br2 / CH2Cl2 / -10 °C 4: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: 97 percent / K2CO3 / acetone / 22 h / Heating 2: 92 percent / Br2 / CH2Cl2 / -10 °C 3: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: 95 percent / POCl3 / 5 h / 65 °C 2: aq.H2SO4; aq.H2O2 / methanol / 10 - 20 °C 3: 17.6 g / benzene; polyglycol-400; aq.NaOH / H2O / 2.5 h / 55 °C / pH 9.0 - 9.5 View Scheme
参考文献
Synthetic Communications, , vol. 36, # 14 p. 1961 - 1965
反应条件
1: 97 percent / hydrazine hydrate; KOH / ethane-1,2-diol / 6 h / 70 - 120 °C 2: 95 percent / POCl3 / 5 h / 65 °C 3: aq.H2SO4; aq.H2O2 / methanol / 10 - 20 °C 4: 17.6 g / benzene; polyglycol-400; aq.NaOH / H2O / 2.5 h / 55 °C / pH 9.0 - 9.5 View Scheme
参考文献
Synthetic Communications, , vol. 36, # 14 p. 1961 - 1965
反应条件
1: NaBr; acetic acid; H2O2 / H2O / 2 h / 20 °C 2: 18 g / CuCl / dimethylformamide / 9 h / 110 °C 3: 90 percent / HCl / hexane / 20 °C 4: 94 percent / magnesium; ethanol / 2 h / 40 - 45 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 16 p. 2401 - 2405
反应条件
1: 18 g / CuCl / dimethylformamide / 9 h / 110 °C 2: 90 percent / HCl / hexane / 20 °C 3: 94 percent / magnesium; ethanol / 2 h / 40 - 45 °C View Scheme
参考文献
Synthetic Communications, , vol. 36, # 16 p. 2401 - 2405
反应条件
1: aq.H2SO4; aq.H2O2 / methanol / 10 - 20 °C 2: 17.6 g / benzene; polyglycol-400; aq.NaOH / H2O / 2.5 h / 55 °C / pH 9.0 - 9.5 View Scheme
参考文献
Synthetic Communications, , vol. 36, # 14 p. 1961 - 1965
