N-(苄氧羰基)-L-苯丙氨酸甲酯合成路线 （共 61 条）
反应条件
TiCl2(OPri)2; diisobutylaluminium hydride 1.) CH2Cl2, toluene, -78 deg C, 2 h, 2.) CH2Cl2, -78 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Kiyooka; Suzuki; Shirouchi; Kaneko; Tanimori
Tetrahedron Letters, 1993 , vol. 34, # 36 p. 5729 - 5732
反应条件
diisobutylaluminium hydride in toluene T=-78°C;
参考文献
Tsubaki, Kazunori; Kusumoto, Tomokazu; Hayashi, Noriyuki; Tanima, Daisuke; Fuji, Kaoru; Kawabata, Takeo
Tetrahedron Asymmetry, 2005 , vol. 16, # 3 p. 739 - 743
反应条件
1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C 2.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C 3.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C 4.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 14 p. 2061 - 2070
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.03 h / 0 °C 1.2: 2 h / 20 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 1 p. 319 - 322
反应条件
Tris buffer; TEA; Celite; α-chymotrypsin in acetonitrile T=30°C; 1 h;
参考文献
Miyazawa, Toshifumi; Nakajo, Shin'ichi; Nishikawa, Miyako; Imagawa, Kiwamu; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 24 p. 2867 - 2868
反应条件
in methanol P=8250660 Torr; 24 h; Ambient temperature;
参考文献
Gante, Joachim; Kalthof, Ulrike; Klaerner, Frank-Gerrit; Weber, Thomas
Angewandte Chemie, 1990 , vol. 102, # 9 p. 1081 - 1082
反应条件
1: 90 percent / p-TsOH / toluene / 100 °C 2: NaHCO3 / methanol; H2O / Heating 3: H2 / Pd/C / methanol / 12 h / 20 °C View Scheme
参考文献
Allevi, Pietro; Anastasia, Mario
Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7663 - 7665
反应条件
1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
2.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C
3.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C
View Scheme
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Izawa, Kunisuke
Organic Letters, 2002 , vol. 4, # 3 p. 447 - 449
反应条件
1: 90 percent / p-TsOH / toluene / 100 °C
2: NaHCO3 / methanol; H2O / Heating
3: H2 / Pd/C / methanol / 12 h / 20 °C
4: HCl / 12 h / 20 °C
5: CF3CO2H / 2 h / 20 °C
View Scheme
参考文献
Allevi, Pietro; Anastasia, Mario
Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7663 - 7665
反应条件
1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
1.2: tetrahydrofuran; heptane; ethylbenzene / 1 h / -45 °C
2.1: SO2Cl2 / CH2Cl2 / 0.5 h / 20 °C
3.1: 20.1 g / aq. HCOOH / 0.33 h / 80 °C
4.1: 77.2 percent / NaBH4 / CH2Cl2; methanol / 0.5 h / 0 °C
5.1: H2 / Pd/C / methanol / 4.5 h / 5 °C
6.1: aq. Na2CO3 / CH2Cl2 / 1 h / 20 °C
7.1: K2CO3 / methanol / 6 h / 20 °C
8.1: 7.55 g / ethanol / 3 h / Heating
9.1: aq. K2CO3 / CH2Cl2 / 8 h / 20 °C
View Scheme
参考文献
Honda, Yutaka; Katayama, Satoshi; Kojima, Mitsuhiko; Suzuki, Takayuki; Kishibata, Naomi; Izawa, Kunisuke
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 14 p. 2061 - 2070
