2-氨基-beta-L-阿拉伯糖呋喃并[1',2':4,5]恶唑啉合成路线 (共 9 条)
反应条件
ammonium hydroxide in methanol T=50°C; Cyclization; 72 h;
参考文献
Camara; Ciurea; Delbederi; Fossey; Fontaine; Gavriliu; Jouenne; Laduree; Aubertin; Kirn
Pharmacy and Pharmacology Communications, 1999 , vol. 5, # 3 p. 225 - 231
反应条件
ammonium hydroxide in methanol T=20°C; 65 h;
参考文献
McGuigan, Christopher; Hinsinger, Karen; Farleigh, Laura; Pathirana, Ranjith N.; Bugert, Joachim J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 1311 - 1322
反应条件
ammonia Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 30-35 ;
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 34-35 ;
反应条件
in ethanol; water 2 h; Reflux;
参考文献
McGuigan, Christopher; Hinsinger, Karen; Farleigh, Laura; Pathirana, Ranjith N.; Bugert, Joachim J.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 1311 - 1322
反应条件
1: aq. ethanol / 5 h / Heating 2: pyridine / 16 h / 5 °C 3: H2SO4 / dimethylformamide; H2O / 3 h / 100 °C 4: NaOMe / methanol / 18 h / 5 °C View Scheme
参考文献
Mourier, Nicolas S.; Eleuteri, Alessandra; Hurwitz, Selwyn J.; Tharnish, Phillip M.; Schinazi, Raymond F.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 12 p. 2759 - 2766
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 31 ;
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
Product distribution / selectivity;
参考文献
Storer, Richard; Moussa, Adel; Wang, Jingyang; Chaudhuri, Narayan C.; Mathieu, Steven; Stewart, Alistair
Patent: US2005/59632 A1, 2005 ;
Location in patent: Page/Page column 32 ;