1.1: ethanol; acetic acid / 20 °C 1.2: NaBH3CN / ethanol / 5 h / 72 °C 1.3: 4N HCl / ethyl acetate; dioxane / 0 °C 2.1: LiOH*H2O / tetrahydrofuran; methanol; H2O / 0 °C 3.1: H2 / Pd/C / aq. ethanol / 2585.81 Torr 4.1: NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme

sodium hydrogencarbonate in water; acetone T=0 - 20°C;