2-溴-1-(2-喹噁啉)乙酮合成路线 （共 4 条）
反应条件
pyridinium hydrobromide perbromide in ethanol; chloroform T=50°C; 16 h;
参考文献
UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin
Patent: WO2012/168733 A1, 2012 ;
Location in patent: Page/Page column 87 ;
WO 2012/168733 A1
反应条件
1: aq. CH2O 2: 63 percent / Br2 / dioxane / Heating View Scheme
参考文献
Sarodnick; Kempter
Pharmazie, 1983 , vol. 38, # 12 p. 829 - 832
反应条件
1: sulfuric acid; silver nitrate; (NH4)2S2O8 / dichloromethane; water / 2.5 h / 40 °C 2: pyridinium hydrobromide perbromide / chloroform; ethanol / 16 h / 50 °C View Scheme
参考文献
UCL BUSINESS PLC; BIRKBECK COLLEGE; WAKSMAN, Gabriel; TABOR, Alethea; SAYER, James; WALLDEN, Karin
Patent: WO2012/168733 A1, 2012 ;
WO 2012/168733 A1
反应条件
hydrogen bromide; bromine 1.) 2 h, 80 deg C; 2.) 3 h, 80 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Sarodnick; Kempter
Pharmazie, 1983 , vol. 38, # 12 p. 829 - 832
