4-乙酰基-2,6-哌嗪二酮合成路线 （共 6 条）
反应条件
1: NH2OH*HCl, K2CO3 / H2O; methanol / 2 h / Heating 2: NaNO2 / H2O; acetic acid / 24 h / 0 °C View Scheme
参考文献
Frehel, Daniel; Maffrand, Jean-Pierre
Heterocycles, 1984 , vol. 22, # 1 p. 143 - 149
参考文献
Franchimont; Dubsky
Recueil des Travaux Chimiques des Pays-Bas, 1917 , vol. 36, p. 89,93
Chem. Zentralbl., 1912 , vol. 83, # II p. 1429
反应条件
sodium methylate in ethylene glycol dimethyl ether; dichloromethane; water
参考文献
Sanofi, S.A.
Patent: US4523013 A1, 1985 ;
反应条件
sodium methylate
1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Frehel, Daniel; Maffrand, Jean-Pierre
Heterocycles, 1983 , vol. 20, # 9 p. 1731 - 1735
反应条件
1: 1.) CH3ONa / 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h
2: 1.) CuCl2*2H2O, 2.) NaBH4 / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.
View Scheme
参考文献
Frehel, Daniel; Maffrand, Jean-Pierre
Heterocycles, 1983 , vol. 20, # 9 p. 1731 - 1735
反应条件
1: 1.) CH3ONa / 1.) DMF, RT, 1 h, 2.) DMF, 120 deg C, 6 h
2: 1.) CuCl2*2H2O, 2.) NaBH4 / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, 0 deg C 45 min.
3: 94 percent / 12N HCl / 0 °C
View Scheme
参考文献
Frehel, Daniel; Maffrand, Jean-Pierre
Heterocycles, 1983 , vol. 20, # 9 p. 1731 - 1735
