4-溴-2-甲基-2-丁醇合成路线 （共 13 条）
反应条件
in diethyl ether T=-20°C; 1 h; Inert atmosphere;
参考文献
Wyeth, LLC
Patent: US2011/105509 A1, 2011 ;
Location in patent: Page/Page column 51 ;
反应条件
in tetrahydrofuran T=0°C; alkylation; 1 h;
参考文献
Fujishima, Toshie; Zhaopeng, Liu; Konno, Katsuhiro; Nakagawa, Kimie; Okano, Toshio; Yamaguchi, Kentaro; Takayama, Hiroaki
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 2 p. 525 - 535
反应条件
methylmagnesium bromide in diethyl ether
反应条件
hydrogenchloride; methylmagnesium bromide in tetrahydrofuran
参考文献
Hoffman-La Roche Inc.
Patent: US5087619 A1, 1992 ;
反应条件
in methanol; chloroform
参考文献
Helvetica Chimica Acta, , vol. 62, p. 1854 - 1865
参考文献
Synthesis, , p. 523 - 524
参考文献
Heslin, Julie C.; Moody, Christopher J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 1417 - 1424
反应条件
iodine; magnesium 1.) diethylether, 2.) diethylether, 20 deg C, 12 h; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 10 p. 769 - 778
反应条件
in N,N-dimethyl-formamide; pentane
参考文献
Hoffman-La Roche Inc.
Patent: US5087619 A1, 1992 ;
