4-(1,3-二氧代异吲哚啉-2-基)丁醛合成路线 （共 27 条）
反应条件
1: With oxalyl dichloride in dichloromethane; dimethyl sulfoxide T=-78°C; 0.333333 h; 2: With triethylamine in dichloromethane; dimethyl sulfoxide T=0°C; 0.5 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1640369 A1, 2006 ;
Location in patent: Page/Page column 26 ;
反应条件
triethylamine in hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate
参考文献
The DuPont Merck Pharmaceutical Company
Patent: US5710159 A1, 1998 ;
反应条件
Pd-BaSO4; xylene T=140°C; Hydrogenation;
参考文献
King; L'Ecuyer; Openshaw
Journal of the Chemical Society, 1936 , p. 352
反应条件
hydrogenchloride in acetone T=20°C; 16 h;
参考文献
Blaney, Paul; Grigg, Ronald; Rankovic, Zoran; Thornton-Pett, Mark; Xu, Juan
Tetrahedron, 2002 , vol. 58, # 9 p. 1719 - 1737
反应条件
hydrogen; Pd-BaSO4 in xylene 6 h; Heatingcatalyst poison; Title compound not separated from byproducts;
参考文献
Vinograd, L. Kh.; Suvorov, N. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 9 p. 984 - 988
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 9 p. 1206 - 1210
反应条件
1: 95 percent / Et3N / tetrahydrofuran / 6 h / Ambient temperature 2: 1 N aq. HCl / acetone / 2 h / Heating View Scheme
参考文献
Teshima, Tadashi; Matsumoto, Takahiro; Wakamiya, Tateaki; Shiba, Tetsuo; Aramaki, Yoshio; Nakajima, Terumi; Kawai, Nobufumi
Tetrahedron, 1991 , vol. 47, # 20-21 p. 3305 - 3312
反应条件
bis(benzonitrile)palladium(II) dichloride; AgNO2; CuCl2·2H2O; nitromethane; oxygen; tert-butyl alcohol T=20°C; Wacker Oxidation; P=760.051 Torr; 6 h;
参考文献
Wickens, Zachary K.; Morandi, Bill; Grubbs, Robert H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 43 p. 11257 - 11260
Angew. Chem., 2013 , vol. 125, # 43 p. 11467 - 11470
反应条件
1: 94 percent / 180 °C 2: thionyl chloride / DMFA / 30 - 70 °C 3: 100 percent / H2 / Pd/BaSO4 / xylene / 6 h / Heating; catalyst poison View Scheme
参考文献
Guzi, Timothy J.; Macdonald, Timothy L.
Tetrahedron Letters, 1996 , vol. 37, # 17 p. 2939 - 2942
反应条件
1: thionyl chloride / DMFA / 30 - 70 °C 2: 100 percent / H2 / Pd/BaSO4 / xylene / 6 h / Heating; catalyst poison View Scheme
参考文献
Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830
反应条件
Rh(acac)(CO)2; 3,3',5,5'-tetra(2,4-difluorophenyl)-2,2',6,6'-tetra((di-1-pyrrolylphosphino)oxy)-1,1'-biphenyl; hydrogen in toluene T=120°C; P=3800.26 Torr; 2 h; Autoclave; regioselective reaction;
参考文献
Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9992 - 9998
