2-(4-吗啉)-4-吡啶胺合成路线 （共 6 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol; dichloromethane P=2585.81 Torr; 12 h;
参考文献
AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.
Patent: WO2012/3283 A1, 2012 ;
Location in patent: Page/Page column 154 ;
WO 2012/003283 A1
反应条件
T=200°C; 1 h; microwave;
参考文献
XCOVERY, INC.
Patent: WO2008/88881 A1, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/088881 A1
反应条件
1: tetrahydrofuran / 20 h / Reflux 2: hydrogen / palladium 10 on activated carbon / dichloromethane; methanol / 12 h / 2585.81 Torr View Scheme
参考文献
AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.
Patent: WO2012/3283 A1, 2012 ;
WO 2012/003283 A1
参考文献
Sazonov,N.V. et al.
Pharmaceutical Chemistry Journal, 1972 , vol. 6, # 3 p. 146 - 149
Khimiko-Farmatsevticheskii Zhurnal, 1972 , vol. 6, # 3 p. 18 - 21
反应条件
1: ethanol 2: Fe / acetic acid View Scheme
参考文献
Sazonov,N.V. et al.
Pharmaceutical Chemistry Journal, 1972 , vol. 6, # 3 p. 146 - 149
Khimiko-Farmatsevticheskii Zhurnal, 1972 , vol. 6, # 3 p. 18 - 21
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 0.5 h; 2: With hydrogen bromide; copper(I) bromide in water T=0 - 60°C; 0.75 h;
参考文献
XCOVERY, INC.
Patent: WO2008/88881 A1, 2008 ;
Location in patent: Page/Page column 51 ;
WO 2008/088881 A1
