5-(4-氯苯基)-2-氧代-1,2-二氢-3-吡啶甲腈合成路线 （共 5 条）
反应条件
sodium methylate in methanol 1.) r.t., 1.5 h, 2.) reflux, overnight;
参考文献
Church; Trust; Albright; Powell
Journal of Organic Chemistry, 1995 , vol. 60, # 12 p. 3750 - 3758
反应条件
1: 2-cyano-acetamide With sodium methylate in methanol T=20°C; 1 h; Inert atmosphere; 2: C11H12ClNO2 in methanol-d1 4 h; RefluxInert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8352 - 8365
反应条件
1.1: trichlorophosphate / 6 h / 0 - 75 °C / |Inert atmosphere 1.2: 1 h / 100 °C / pH 11 2.1: sodium methylate / methanol / 1 h / 20 °C / |Inert atmosphere 2.2: 4 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8352 - 8365
参考文献
Eli Lilly and Company
Patent: US4405552 A1, 1983 ;
反应条件
trichlorophosphate T=120 - 130°C; Inert atmosphere;
参考文献
Hogenkamp, Derk J.; Ford-Hutchinson, Thomas A.; Li, Wen-Yen; Whittemore, Edward R.; Yoshimura, Ryan F.; Tran, Minhtam B.; Johnstone, Timothy B. C.; Bascom, Gavin D.; Rollins, Hannah; Lu, Lena; Gee, Kelvin W.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8352 - 8365
