((1,3-二溴丙烷-2-基氧基)甲基)苯合成路线 （共 15 条）
反应条件
sodium ethanolate; sodium in ethanol
参考文献
Nippon Shoji Kaisha Ltd.
Patent: US6080750 A1, 2000 ;
反应条件
1: Na 2: (i) (saponification), (ii) (decarboxylation) View Scheme
参考文献
Slade, Joel; Bajwa, Joginder; Liu, Hui; Parker, David; Vivelo, James; Chen, Guang-Pei; Calienni, John; Villhauer, Edwin; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 825 - 835
反应条件
sodium hydride in N,N-dimethyl-formamide
T=140°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1748048 A1, 2007 ;
Location in patent: Page/Page column 54 ;
反应条件
n-butyllithium in tetrahydrofuran
1.) -70 degC, 2h, 2.) room temperature, 15.5h;
参考文献
Ogura, K.; Yamashita, M.; Suzuki, M.; Furukawa, S.; Tsuchinashi, G.
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 6 p. 1637 - 1642
反应条件
1: sodium methylate / |Inert atmosphere
2: potassium hydroxide / ethanol / |Inert atmosphere
3: hydrogenchloride / |Inert atmosphere
View Scheme
参考文献
Slade, Joel; Bajwa, Joginder; Liu, Hui; Parker, David; Vivelo, James; Chen, Guang-Pei; Calienni, John; Villhauer, Edwin; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J.
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 825 - 835
