N,N'-二(2-羟基苄基)乙二胺-N,N'-二乙酸合成路线 （共 5 条）
反应条件
1: H2Salen With hydrogen; palladium on activated charcoal in methanol T=50°C; P=3800.26 Torr; 3 h; Autoclave; 2: formyl formic acid With hydrogen; triethylamine in methanol T=50°C; P=7600.51 Torr; 15 h; Product distribution / selectivity;
参考文献
Przedsiebiorstwo Produkcyjno-Consultingowe ADOB sp. z o.o. sp. k.
Patent: EP2039679 A1, 2009 ;
Location in patent: Page/Page column 10; 11 ;
反应条件
1: 97 percent 2: 22 percent / 30percent H2O2, sodium hydroxide / ethanol; H2O / 3 h / 5 - 10 °C 3: 1.) Fe(III) salt, 2.) 8-hydroxyquinoline / 1.) Fe(III) salt, neutral or alkaline pH, 3-4 h, RT; 2.) HCl, pH = 5.0, 8-hydroxyquinoline/ethanol, 50 deg C View Scheme
参考文献
Martell, Arthur E.; Motekaitis, Ramunas J.; Clarke, Eric T.; Harrison, J.J.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 449 - 456
反应条件
1: 22 percent / 30percent H2O2, sodium hydroxide / ethanol; H2O / 3 h / 5 - 10 °C 2: 1.) Fe(III) salt, 2.) 8-hydroxyquinoline / 1.) Fe(III) salt, neutral or alkaline pH, 3-4 h, RT; 2.) HCl, pH = 5.0, 8-hydroxyquinoline/ethanol, 50 deg C View Scheme
参考文献
Martell, Arthur E.; Motekaitis, Ramunas J.; Clarke, Eric T.; Harrison, J.J.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 449 - 456
反应条件
hydrogenchloride; 8-hydroxy-quinoline 1.) Fe(III) salt, neutral ol alkaline pH, 3-4 h, RT; 2.) HCl, pH = 5.0, 8-hydroxyquinoline/ethanol, 50 deg C; Multistep reaction;
参考文献
Martell, Arthur E.; Motekaitis, Ramunas J.; Clarke, Eric T.; Harrison, J.J.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 449 - 456
反应条件
thionyl chloride
T=60°C; 3 h;
参考文献
Pitt, C. G.; Bao, Y.; Thompson, J.; Wani, M. C.; Rosenkrantz, H.; Metterville, J.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1231 - 1237
