2-甲基-3-硝基-5-噻吩甲酸合成路线 （共 15 条）
反应条件
nitric acid; acetic anhydride T=-78 - 20°C; 1.16667 h; Cooling with acetone-dry ice;
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 82 ;
反应条件
nitric acid; acetic anhydride
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 51, p. 1134,1141
Journal of the American Chemical Society, , vol. 73, p. 3812
Arkiv foer Kemi, , vol. 16, p. 563,564, 577, 582
反应条件
1.1: AlCl3 / 1,2-dichloro-ethane / 45 - 50 °C 1.2: NaOCl / 70 - 80 °C 2.1: HNO3; H2SO4 / 0 - 5 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1221 - 1230
反应条件
1.1: NH2NH2*H2O; KOH / ethane-1,2-diol / 180 °C 2.1: AlCl3 / 1,2-dichloro-ethane / 45 - 50 °C 2.2: NaOCl / 70 - 80 °C 3.1: HNO3; H2SO4 / 0 - 5 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1221 - 1230
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 51, p. 1134,1141
反应条件
1: Raney nickel 2: aqueous hydrochloric acid View Scheme
参考文献
Gol'dfarb et al.
Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 3636,3639; engl. Ausg. S. 3596, 3598
反应条件
ammonia; sodium in ethanol
参考文献
Gol'dfarb, Ya.L.; Zakharov, E.P.; Stoyanovich, F.M.; Marakatkina, M.A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, # 10 p. 2136 - 2139
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 10 p. 2338 - 2341
反应条件
1: thionyl chloride; benzene
View Scheme
参考文献
Campaigne; Grose
Journal of the American Chemical Society, 1951 , vol. 73, p. 3812
反应条件
hydrogen cation
Heating;
参考文献
Rajender Kumar; Raju; Satish Goud; Sailaja; Sarma; Om Reddy; Prem Kumar; Krishna Reddy; Suresh; Hegde, Pragathi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 1221 - 1230
反应条件
sulfuric acid; nitric acid
参考文献
Campaigne; Grose
Journal of the American Chemical Society, 1951 , vol. 73, p. 3812
