6-氨基烟酸甲酯合成路线

参考文献

Berthel, Steven Joseph; Chen, Li; Corbett, Wendy Lea; Feng, LiChun; Haynes, Nancy-Ellen; Kester, Robert Francis; So, Sung-Sau; Tilley, Jefferson Wright
Patent: US2011/144105 A1, 2011 ;

36052-24-16-氨基烟酸甲酯

106730-54-5奥普力农

参考文献

Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567

36052-24-16-氨基烟酸甲酯

116355-16-9咪唑并[1,2-a]吡啶-6-甲醛

参考文献

Chemical and Pharmaceutical Bulletin, , vol. 39, # 6 p. 1556 - 1567

36052-24-16-氨基烟酸甲酯

113293-71-3(6-氨基-3-吡啶基)甲醇

参考文献

Tibotec Pharmaceuticals Ltd.
Patent: WO2007/113290 A1, 2007 ;
Location in patent: Page/Page column 28 ;

4360-63-82-溴甲基-1,3-二氧戊烷+

36052-24-16-氨基烟酸甲酯

136117-69-6咪唑并[1,2-a]吡啶-6-甲酸甲酯

参考文献

METHYLGENE, INC.
Patent: WO2005/30704 A1, 2005 ;
Location in patent: Page/Page column 247 ;

107-20-0一氯乙醛+

36052-24-16-氨基烟酸甲酯

136117-69-6咪唑并[1,2-a]吡啶-6-甲酸甲酯

参考文献

Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590

36052-24-16-氨基烟酸甲酯+

17157-48-1溴乙醛

136117-69-6咪唑并[1,2-a]吡啶-6-甲酸甲酯

参考文献

Li, Qun; Woods, Keith W.; Claiborne, Akiyo; Gwaltney, Ii, Stephen L.; Barr, Kenneth J.; Liu, Gang; Gehrke, Laura; Credo; Hui, Yu Hua; Lee, Jang; Warner, Robert B.; Kovar, Peter; Nukkala, Michael A.; Zielinski, Nicolette A.; Tahir, Stephen K.; Fitzgerald, Michael; Kim, Ki H.; Marsh, Kennan; Frost, David; Ng, Shi-Chung; Rosenberg, Saul; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 465 - 469

36052-24-16-氨基烟酸甲酯+

2032-35-12-溴-1,1-二乙氧基乙烷

136117-69-6咪唑并[1,2-a]吡啶-6-甲酸甲酯

参考文献

Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567

36052-24-16-氨基烟酸甲酯

132213-07-1咪唑并[1,2-a]吡啶-6-甲醇

参考文献

Hughes, Samantha J.; Millan, David S.; Kilty, Iain C.; Lewthwaite, Russell A.; Mathias, John P.; Reilly, Mark A.O.; Pannifer, Andrew; Phelan, Anne; Stuehmeier, Frank; Baldock, Darren A.; Brown, David G.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6586 - 6590

36052-24-16-氨基烟酸甲酯+

24424-99-5二碳酸二叔丁酯

144186-11-86-[(叔丁氧基羰基)氨基]烟酸甲酯

参考文献

Kempf, Dale J.; Sham, Hing L.; Marsh, Kennan C.; Flentge, Charles A.; Betebenner, David; Green, Brian E.; McDonald, Edith; Vasavanonda, Sudthida; Saldivar, Ayda; Wideburg, Norman E.; Kati, Warren M.; Ruiz, Lisa; Zhao, Chen; Fino, Lynnmarie; Patterson, Jean; Molla, Akhteruzzaman; Plattner, Jacob J.; Norbeck, Daniel W.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 602 - 617