5-氨基吡啶-3-羧酸甲酯合成路线 （共 15 条）
反应条件
ammonium hydroxide T=20°C; 72 h;
参考文献
Boovanahalli, Shanthaveerappa K.; Jin, Xuejun; Jin, Yinglan; Kim, Jin Hwan; Dat, Nguyen Tien; Hong, Young-Soo; Lee, Jeong Hyung; Jung, Sang-Hun; Lee, Kyeong; Lee, Jung Joon
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 22 p. 6305 - 6310
反应条件
1: aqueous H2sif6; ethanol / Behandeln der Suspension des Hexafluorosilicats in Essigsaeure mit Aethylnitrit und Erhitzen des Reaktionsprodukts in Toluol 2: NH3; methanol View Scheme
参考文献
Hawkins; Roe
Journal of Organic Chemistry, 1949 , vol. 14, p. 328,331
反应条件
1: methyl 5-amino-3-pyridinecarboxylate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With tert.-butylnitrite in acetonitrile T=80°C; 2 h; 2: iodobenzene With tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Jin, Liang; Zheng, Zhitong; Meng, He; Mo, Fanyang; Wang, Xi; Zhang, Yan; Wang, Jianbo
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1923 - 1933
反应条件
1: With sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane 2: With sodium hydrogencarbonate in dichloromethane; 1,2-dichloro-ethane
参考文献
EVOTEC AG; TAYLOR, Steven; HALLETT, David James; TOWNSEND, Robert James
Patent: WO2010/130638 A1, 2010 ;
Location in patent: Page/Page column 80 ;
WO 2010/130638 A1
反应条件
1.1: 93 percent / LiAlH4 / tetrahydrofuran / 21 h / 20 °C
2.1: NaNO2 / 0.5 h
2.2: 83 percent / aq. H2SO4 / 1 h / 70 °C
View Scheme
参考文献
Jensen, Henrik Helligso; Lyngbye, Laila; Jensen, Astrid; Bols, Mikael
Chemistry - A European Journal, 2002 , vol. 8, # 5 p. 1218 - 1226
