3-氨基吡啶-2-甲酸甲酯合成路线 （共 8 条）
反应条件
1: With sulfuric acid T=80°C; 168 h; 2: With sodium carbonate in water pH=~ 7;
参考文献
MERCK SHARP and DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason
Patent: WO2005/49613 A1, 2005 ;
Location in patent: Page/Page column 39 ;
WO 2005/049613 A1
反应条件
in methanol; ethyl acetate T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 53-54 ;
参考文献
US5801183 A1, ;
US 5801183 A
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 9 p. 2754 - 2761
参考文献
Zhou, Zhang-Lin; Navratil, James M.; Cai, Sui Xiong; Whittemore, Edward R.; Espitia, Stephen A.; Hawkinson, Jon E.; Tran, Minhtam; Woodward, Richard M.; Weber, Eckard; Keana, John F.W.
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 8 p. 2061 - 2071
反应条件
1: 10 percent / NaOBr; aq. NaOH / 2 h / 20 - 85 °C 2: 52 percent / methanol / 0.5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 8 p. 2061 - 2071
反应条件
1.1: acetic anhydride / 120 °C 1.2: 56 percent / acetamide / 2.5 h / Heating 2.1: 10 percent / NaOBr; aq. NaOH / 2 h / 20 - 85 °C 3.1: 52 percent / methanol / 0.5 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 9, # 8 p. 2061 - 2071
反应条件
1: With sulfuric acid; bromine; acetic acid in water 2: With sodium hydroxide; water pH=6;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 54 ;
