1: FSO3H / various solvent(s) / 0.25 h / -78 °C 2: 88 percent / aq. KOH / ethanol / 0.5 h / Heating 3: 131.8 mg / pyridine / CH2Cl2 / 2.5 h / 0 °C 4: 57 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating View Scheme

potassium hydroxide in methanol T=20°C; Hydrolysis;

lipase PS-D T=25°C; 24 h;

1: 1) Mg, CuI / 1) THF, -20 deg C, 0.5 h, 2) -15 deg C, 3 h, then 3 h, room temperature 2: 97 percent / H2 / 5percent Pd-C / ethanol / 30 h View Scheme

1: FSO3H / various solvent(s) / 0.25 h / -78 °C 2: 88 percent / aq. KOH / ethanol / 0.5 h / Heating View Scheme