6-甲基-2,3-二氢喹啉-4-酮合成路线 （共 11 条）
反应条件
trifluorormethanesulfonic acid in dichloromethane T=0 - 18°C; Fries rearrangement; 1 h; Inert atmosphere;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
methanesulfonic acid; phosphorous pentoxide T=90°C; 12 h;
参考文献
Layek, Mohosin; Reddy M., Appi; Dhanunjaya Rao; Alvala, Mallika; Arunasree; Islam, Aminul; Mukkanti; Iqbal, Javed; Pal, Manojit
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 4 p. 1004 - 1007
反应条件
1: potassium carbonate / dichloromethane / 0 - 20 °C 2: sodium t-butanolate / N,N-dimethyl-formamide / 0 - 20 °C 3: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 0 - 20 °C View Scheme
参考文献
Wang, Jian; Wang, Shao-Jie; Song, Dan-Dan; Jing, Yong-Kui; Cheng, Mao-Sheng
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2823 - 2826
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed 2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere View Scheme
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: sodium t-butanolate / N,N-dimethyl-formamide / 0 - 20 °C 2: trifluorormethanesulfonic acid / 1,2-dichloro-ethane / 2 h / 0 - 20 °C View Scheme
参考文献
Fang, Yuesi; Rogness, Donald C.; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6262 - 6270
参考文献
Wang, Jian; Wang, Shao-Jie; Song, Dan-Dan; Jing, Yong-Kui; Cheng, Mao-Sheng
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2823 - 2826
反应条件
1.1: sodium hydroxide / |Reflux 1.2: |Acidic conditions 2.1: polyphosphoric acid View Scheme
参考文献
Wang, Jian; Wang, Shao-Jie; Song, Dan-Dan; Jing, Yong-Kui; Cheng, Mao-Sheng
Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 2823 - 2826
参考文献
Clemo; Perkin
Journal of the Chemical Society, 1925 , vol. 127, p. 2303
反应条件
palladium 10 on activated carbon; sodium hydroxide in water; isopropyl alcohol 16 h; Inert atmosphereReflux;
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: 6-methyl-2,3-dihydroquinolin-4(1H)-one With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C; Inert atmosphere;
2: methyl iodide in N,N-dimethyl-formamide; mineral oil
T=80°C;
参考文献
Fang, Yuesi; Rogness, Donald C.; Larock, Richard C.; Shi, Feng
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6262 - 6270
