[1-(4-溴苯基)-环丙基]氨基甲酸叔丁酯合成路线 （共 5 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=0 - 20°C; 18 h;
参考文献
ArQule, Inc.
Patent: US2012/108574 A1, 2012 ;
Location in patent: Page/Page column 113 ;
反应条件
diphenyl phosphoryl azide; triethylamine 17 h; Heating / refluxNeat (no solvent);
参考文献
Allergan Sales, Inc.
Patent: US6369225 B1, 2002 ;
Location in patent: Page column 42, 112 ;
反应条件
1: 1-(4-bromophenyl)-cyclopropanecarboxylic acid; tert-butyl alcohol With diphenyl phosphoryl azide; triethylamine 15 h; Heating / reflux; 2: di-tert-butyl dicarbonate in tert-butyl alcohol 15 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/63239 A1, 2005 ;
Location in patent: Page/Page column 129 ;
WO 2005/063239 A1
反应条件
hydrogenchloride in tetrahydrofuran; methanol; water T=25 - 35°C; 20 h;
参考文献
Allergan Sales, Inc.
Patent: US6369225 B1, 2002 ;
Location in patent: Page column 42, 112-113 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C;
参考文献
MCCONNELL, Darryl; BETZEMEIER, Bodo; GERSTBERGER, Thomas; IMPAGNATIELLO, Maria; STEURER, Steffen; van der VEEN, Lars; WEYER-CZERNILOFSKY, Ulrike
Patent: US2008/81802 A1, 2008 ;
Location in patent: Page/Page column 9; 10 ;
