1-(2-溴苯基)-2-苯基-1-乙酮合成路线 （共 17 条）
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 49 h;
参考文献
GENELABS TECHNOLOGIES, INC
Patent: WO2005/12288 A1, 2005 ;
Location in patent: Page/Page column 188 ;
反应条件
potassium tert-butylate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene T=80°C; 0.75 h; Inert atmosphereSchlenk technique;
参考文献
Mahendar, Lodi; Satyanarayana, Gedu
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2059 - 2074
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene T=120°C; 22 h; 2: With hydrogenchloride in toluene T=100°C; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
1: With titanium tetrachloride; tert-butylamine in toluene T=120°C; 22 h; 2: With hydrogenchloride in toluene T=100°C; 24 h; 3: With potassium phosphate; copper(l) iodide in N,N-dimethyl-formamide T=105°C; 22 h; Further stages.;
参考文献
Ackermann, Lutz; Kaspar, Ludwig T.
Journal of Organic Chemistry, 2007 , vol. 72, # 16 p. 6149 - 6153
反应条件
hydrogenchloride Heating;
参考文献
Christy; Colton; Mackay; Staas; Wong; Engelhardt; Torchiana; Stone
Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 421 - 430
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 2042185/, (iii) aq. citric acid 2: aq. HCl / Heating View Scheme
参考文献
Christy; Colton; Mackay; Staas; Wong; Engelhardt; Torchiana; Stone
Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 421 - 430
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 2042185/, (iii) aq. citric acid 2: aq. HCl / Heating View Scheme
参考文献
Christy; Colton; Mackay; Staas; Wong; Engelhardt; Torchiana; Stone
Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 421 - 430
反应条件
1: diethyl ether / 3 h / 0 - 20 °C / |Inert atmosphere 2: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 20 °C / |Inert atmosphere 3: palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; potassium tert-butylate / toluene / 0.75 h / 80 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Mahendar, Lodi; Satyanarayana, Gedu
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2059 - 2074
反应条件
1: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 20 °C / |Inert atmosphere 2: palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; potassium tert-butylate / toluene / 0.75 h / 80 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Mahendar, Lodi; Satyanarayana, Gedu
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2059 - 2074
反应条件
1: thionyl chloride 2: diethyl ether / Behandeln des Reaktionsgemisches mit Eis und wss. HCl View Scheme
参考文献
Borsche; Scriba
Justus Liebigs Annalen der Chemie, 1939 , vol. 541, p. 283,290
