5-溴-2,4-二氯嘧啶合成路线 （共 29 条）
参考文献
PCR, Incorporated
Patent: US4299961 A1, 1981 ;
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate T=90°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 23 p. 7169 - 7173,5
参考文献
American Chemical Journal, , vol. 33, p. 443
反应条件
in tetrahydrofuran T=20°C;
参考文献
Glaxo Group Limited
Patent: WO2007/113232 A1, 2007 ;
Location in patent: Page/Page column 106-107 ;
参考文献
Hilbert; Jansen
Journal of the American Chemical Society, 1934 , vol. 56, p. 134,138
参考文献
Hilbert; Jansen
Journal of the American Chemical Society, 1934 , vol. 56, p. 134,138
反应条件
1: methanol With sodium 2: 5-Bromo-2,4-dichloror-pyrimidine 2 h; Reflux;
参考文献
Mukherjee, Soumita; Ghorai, Binay K.
Synthetic Communications, 2010 , vol. 40, # 13 p. 1939 - 1943
反应条件
methanol T=20°C; 4 h;
参考文献
Almirall, S.A.; Eastwood, Paul Robert; Gonzalez Rodriguez, Jacob; Bach Taña, Jordi; Pages Santacana, Lluis Miquel; Taltavull Moll, Joan; Caturla Javaloyes, Juan Francisco
Patent: EP2338888 A1, 2011 ;
Location in patent: Paragraph 0173; 0174 ;
EP 2338888 A1
反应条件
in acetonitrile T=20°C; 24 h;
参考文献
SCHERING AKTIENGESELLSCHAFT
Patent: WO2007/71455 A1, 2007 ;
Location in patent: Page/Page column 252-253 ;
WO 2007/071455 A1
反应条件
in methanol 1.) 0 deg C, 2 h, 2.) room temp., overnight;
参考文献
Wojtowicz-Rajchel, Hanna; Suchowiak, Marek; Fiedorow, Piotr; Golankiewicz, Krzysztof
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 4 p. 841 - 845
