5-溴-2,4-二氯嘧啶合成路线 （共 29 条）
反应条件
N-ethyl-N,N-diisopropylamine in diethyl ether; butan-1-ol
参考文献
Pease, Elizabeth Janet; Breault, Gloria Anne; Morris, Jeffrey James
Patent: US2003/149064 A1, 2003 ;
反应条件
1: benzyl alcohol With sodium hydride in toluene T=0°C; 1 h; 2: 5-Bromo-2,4-dichloror-pyrimidine in toluene
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/125061 A1, 2007 ;
Location in patent: Page/Page column 48 ;
WO 2007/125061 A1
反应条件
sodium hydride in toluene T=20°C; 18 h;
参考文献
Seley, Katherine L.; Salim, Samer; Zhang, Liang; O'Daniel, Peter I.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1612 - 1619
参考文献
PCR, Incorporated
Patent: US4299961 A1, 1981 ;
参考文献
PCR, Incorporated
Patent: US4299961 A1, 1981 ;
反应条件
in methanol T=0 - 20°C; 3.66667 h;
参考文献
Teno, Naoki; Gohda, Keigo; Wanaka, Keiko; Tsuda, Yuko; Sueda, Takuya; Yamashita, Yukiko; Otsubo, Tadamune
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2339 - 2352
参考文献
PCR, Incorporated
Patent: US4299961 A1, 1981 ;
参考文献
PCR, Incorporated
Patent: US4299961 A1, 1981 ;
反应条件
in toluene Ambient temperature;
参考文献
Wojtowicz-Rajchel, Hanna; Suchowiak, Marek; Fiedorow, Piotr; Golankiewicz, Krzysztof
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 4 p. 841 - 845
反应条件
ammonia in methanol T=20°C;
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; NOBLE, Stewart, A.
Patent: WO2011/112766 A2, 2011 ;
Location in patent: Page/Page column 125; 126 ;
